September is Childhood Cancer Awareness Month, and it’s a great time to get involved on behalf of children fighting childhood cancer!  

There are so many different ways for you to help kids with cancer! No matter how you decide to get involved, the important thing to know is that your actions matter to children and families fighting childhood cancer. 

Here are five ways you can help kids with cancer during Childhood Cancer Awareness Month:

1. Make a donation

Childhood Cancer Awareness Month is a great time to donate to ACCO’s ongoing effort to develop and offer free resources to families facing a cancer diagnosis. Our resources are designed to help children, teens, siblings, and families cope with the medical, emotional, and psychological hardships of childhood cancer. Thanks to your help, we can continue to offer all our resources free of charge to families facing a cancer diagnosis. 

Donate

2. Go Gold for Kids with Cancer®

Gold is the color of the month during September and what better way to raise awareness about childhood cancer than to incorporate the gold ribbon into your fundraiser! All you need to do is select your theme–a sports night, a dance party, a fashion show, a bake sale–and highlight the color gold. As a special bonus, ACCO will provide gold-themed awareness items to help you paint your community GOLD for Childhood Cancer Awareness Month.

Find more ideas for Go Gold fundraisers here!

3. Host a PJammin® Party

Kids in treatment for childhood cancer can spend weeks–even months–in the hospital. PJammin® events help people in your community stand in solidarity with kids who often live in their pjs at the hospital, while raising money for a great cause. Work with your school or place of work to organize a day for everyone to show up in their pjs in exchange for a donation. It’s easy, it’s fun, and it’s a great way to raise awareness during Childhood Cancer Awareness Month!

PJammin® for Kids with Cancer

4. Join the Take a Pop, Share a Smile Program

For kids with cancer, a frozen pop can be more than just a tasty treat; it can also help ease the discomfort of some of chemo’s side effects. Through our Take a Pop, Share a Smile program, our partner JelSert provides a free special freezer and unlimited supply of ice pops to hospitals across the U.S. Help us expand our program by requesting a freezer for your local children’s hospital! 

Request a Freezer

5. Advocate for Kids with Cancer

ACCO and the childhood cancer community has a goal for every state to proclaim this month — September — Childhood Cancer Awareness Month. We need your help! Join forces with us and make your voice heard! The process is easy: simply visit our Voter Voice Action Center where ACCO has provided a pre-written email for you to send to your governor. It only takes a few minutes to make a powerful statement on behalf of children fighting childhood cancer!

Proclaim September as Childhood Cancer Awareness Month in your state

About the American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

Key Statistics Relating to Childhood Non-Hodgkin Lymphoma (NHL)

Non-Hodgkin Lymphoma (NHL) is an aggressive and diffuse type of cancer that grows within a child’s immune system, specifically within a type of white blood cell known as a lymphocyte. Non-Hodgkin Lymphoma accounts for about 5% of all childhood cancers (Hodgkin Lymphoma accounts for around 3% of all childhood cancers). In general, the risk of NHL decreases with age; it is uncommon in children under the age of 3 and over the age of 14. It is more commonly diagnosed in boys than girls. In children, there are three distinct types of NHL: Lymphoblastic lymphoma (LBL), Burkitt lymphoma (also called small, non-cleaved cell lymphoma), and large cell lymphomas. Burkitt lymphoma accounts for about 40% of all NHL diagnoses in the United States.

These general statistics are interesting but of course the most important statistic for many people is the long-term survival rate for children with NHL. In other words, most people want to know “what is the expected life span of someone with Non-Hodgkin Lymphoma?” Generally speaking, oncologists don’t talk about “curing” childhood cancer; instead, they utilize something called the 5-year survival rate. This key statistic refers to the percentage of children who are still alive five years after their treatment is complete. For most children with NHL, this type of cancer is unlikely to return once a child has been “cancer free” for five years (although this does not address the risk of secondary cancers stemming from the original cancer treatment).

As always with statistics, however, it is important to look at them with a degree of caution. First, and most importantly, a general statistic can never predict what will happen with one specific child. Each child’s prognosis depends heavily on their unique diagnosis. Second, by definition, the 5-year survival rate looks at children who completed treatment at least five years ago, if not longer. Fortunately, research into new and better treatment options for NHL and other types of childhood cancers is progressing more rapidly than ever before, so today’s treatment options may be more effective than those available five or more years ago.

Prognosis of Non-Hodgkin Lymphoma by Type

The good news is that, in general, NHL responds well to chemotherapy; in other words, chemotherapy is usually able to kill most NHL cells fairly quickly. Moreover, as research into different types of drugs and different combinations of drugs progresses, oncologists are finding even more effective methods of targeting NHL. However, the specific prognosis of each child will depend on the type of NHL they have been diagnosed with, the stage of the cancer, how well it responds, and the general health of the child. Your child’s oncologist will be able to provide you with an answer to this question that is specific to your child.

The prognosis for the three main types of Non-Hodgkin Lymphoma in children is broken down thusly:

• Lymphoblastic lymphoma (LBL): Like Acute lymphoblastic leukemia (ALL), LBL grows in immature lymphocytes known as lymphoblasts. LBL responds well to intensive chemotherapy, and the 5-year survival rate for Stage I or II LBL is greater than 90%. The 5-year survival rate for Stage III or Stage IV LBL is generally greater than 80%.

• Burkitt lymphoma (small, non-cleaved cell lymphoma): Burkitt lymphoma starts in the abdomen, and can sometimes grow in the form of a tumor; therefore, surgery in addition to chemotherapy may be required. Burkitt lymphoma is one of the fastest-growing cancers and must be treated very aggressively. As with LBL, Stages I and II can be treated very successfully, with long-term survival rates greater than 90%, while the long-term survival rate for Stages III and IV is between 80 and 90%.

• Large cell lymphomas: Large cell lymphomas grow from mature T or B cell lymphocytes. Generally speaking, this type of NHL grows more slowly than other lymphomas and is less likely to spread to the bone marrow or brain. There are two main subtypes: anaplastic large cell lymphoma (ALCL) and diffuse large B-cell lymphoma (DLBCL). Again, for Stages I and II, the 5-year survival rate is greater than 90%, and ranges between 80 and 90% for more advanced stages (III or IV). The long-term survival rate for ALCL, however, is between 60 and 75%.

More about Childhood Non-Hodgkin Lymphoma Cancers:

• About Childhood Non-Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Non-Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Non-Hodgkin Lymphoma Cancer?
• Non-Hodgkin Lymphoma Cancer Treatment
• Non-Hodgkin Lymphoma Cancer – Stages and Prognosis
• After Treatment – Living as a Childhood Non-Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphoblastic leukemia (ALL), Acute myelogenous leukemia (AML), Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

For additional information about childhood cancer or on ACCO, or to order resources for you or your child, please visit our website at www.acco.org.

Together, we can make a difference. Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

Childhood Non-Hodgkin Lymphoma Cancer Treatment

Non-Hodgkin Lymphoma (NHL) forms within the body’s immune system, specifically within a type of white blood cell called a lymphocyte (B cells or T cells). Although there are three distinct types of NHL in children, there are two common characteristics of this particular form of cancer that must be taken into account when developing an appropriate treatment plan. First, NHL in children is almost always considered “high grade”, meaning that it is likely to grow quickly and aggressively. Second, NHL in children is considered diffuse, meaning it is likely to be found throughout the body. Because of these two characteristics, most oncologists start with the assumption that there are more cancerous cells present than can be detected with imaging and blood tests.

Because of the diffuse nature of Non-Hodgkin Lymphoma, chemotherapy (often called “chemo” for short) is usually the most effective treatment option. Chemotherapy involves targeting the cancerous cells with specific combinations of anti-cancer drugs. In most cases, the drugs are administered in pill form and/or delivered directly into the blood stream through an IV in order to kill cancerous cells throughout the body. In some cases, chemotherapy drugs may be administered directly into the spinal fluid (called intrathecal chemo) in order to target cancer cells that may have spread into the brain and/or spinal cord. NHL usually responds well to chemotherapy.

Although chemotherapy is—in general—the preferred treatment option for children with NHL, the specific combination and dosages of chemo drugs and the duration of treatment are unique to each child. The intensity of treatment will depend in large part on the type and stage of the lymphoma, as well as the general health of the child and how well the lymphoma responds to treatment. Generally speaking, Stage III and Stage IV NHL will require more intensive chemotherapy than Stage I or II NHL, and may involve some limited radiation therapy as well. Except in the case of Burkitt lymphoma, where surgery may be used to remove a tumor growing in one specific area of the body, surgery is almost never effective against this type of diffuse cancer, and therefore only rarely utilized as part of the treatment plan.

About Chemotherapy for Non-Hodgkin Lymphoma

Chemotherapy treatment for Non-Hodgkin Lymphoma is usually administered in three distinct phases.

• Induction: The initial phase of chemo is designed to eliminate 99% of cancer cells in order to achieve “remission” (“remission” is not the same as a “cure”). Induction usually lasts for about a month—with daily and/or weekly treatments—and can be extremely intense, especially for Stage III and Stage IV diagnoses.
• Consolidation (also called intensification): Often even more intense than the initial induction phase, consolidation is intended to kill any remaining cancerous cells and inhibit the growth of new, drug-resistant cancer cells. This phase of treatment usually lasts one to two months, or longer if necessary.
• Maintenance: If the lymphoma responds well to induction and consolidation, most children will undergo a maintenance phase to prevent the cancer from returning. The maintenance phase is usually much less intensive, involving the administration of chemotherapy for brief periods every 4-8 weeks or so. Maintenance can last up to 2 years, or perhaps even longer, depending on the intensity of the treatment plan and how well the lymphoma responds to treatment.

Because Non-Hodgkin Lymphoma is considered a “high grade” type of cancer that grows quickly and aggressively, it is important to start chemotherapy as soon as possible after diagnosis. Moreover, if the lymphoma is diagnosed as Stage III or Stage IV where the cancer cells are growing and replicating quite quickly, chemotherapy will be more intensive, requiring short treatment cycles with less rest in between each cycle. Stage III and Stage IV cancers will also almost always require intrathecal chemotherapy, and may involve radiation therapy as well, especially if cancer cells have definitely been found in or near the spinal cord and/or brain.

More about Childhood Non-Hodgkin Lymphoma Cancers:

• About Childhood Non-Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Non-Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Non-Hodgkin Lymphoma Cancer?
• Non-Hodgkin Lymphoma Cancer Treatment
• Non-Hodgkin Lymphoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Non-Hodgkin Lymphoma Cancer?
• After Treatment – Living as a Childhood Non-Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

For additional information about childhood cancer or on ACCO, or to order resources for you or your child, please visit our website at www.acco.org.

Together, we can make a difference. Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

What Causes Non-Hodgkin Lymphoma in Children?

Currently, scientists do not know what causes non-Hodgkin lymphoma in children. Non-Hodgkin lymphoma is a type of cancer associated with the immune system because it begins in a type of white blood cell called a lymphocyte. Normally, lymphocytes, like other healthy cells, grow, replicate, and then die. For some reason, DNA changes within certain lymphocytes cause them to grow into cancerous cells, which then divide into more cancerous cells. Why these DNA changes lead to this change is unknown, however.

Because non-Hodgkin lymphoma is associated with the immune system, there is a link between the development of NHL in some children and a compromised immune system such as associated with Epstein-Barr Virus or HIV infection. EBV, for instance, infects B lymphocytes, potentially causing them to have an increased risk of gene changes associated with NHL. However, it is important to note that the vast majority of children here in the United States who are diagnosed with NHL do not have EPV or a compromised immune system. What causes NHL in these children is unknown.

What are the Risk Factors for Non-Hodgkin Lymphoma?

A “risk factor” is anything that may impact a child’s changes of developing cancer. For example, in adults, risk factors for cancer sometimes include lifestyle choices such as smoking and tobacco use. For children, however, lifestyle choices are not believed to be linked to the development of cancer, so if there are any known risk factors for childhood cancers, they are usually genetic or otherwise immutable.

The most common risk factors for non-Hodgkin lymphoma include:

Age, gender, and race: although scientists to do not understand why, NHL is more common in older children than younger children. It is more common in boys than girls and more common in white children than black children.

Weakened immune system: a compromised immune system has been linked with a higher risk of developing childhood NHL. The immune system may be compromised due to: an underlying genetic condition (such as severe combined immunodeficiency syndrome (SCID), common variable immunodeficiency, Ataxia-telangiectasia, or X-linked lymphoproliferative syndrome); an organ transplant involving immuno-suppressive drugs required to prevent organ rejection; and/or HIV/AIDS.

Radiation exposure: High levels of radiation exposure—such as survivors of atomic bombs or nuclear reactor accidents—have an elevated risk of developing some types of cancers, including NHL. Lower levels of radiation such as from x-rays are not known to be linked to the development of NHL; however, physicians generally try to avoid any unnecessary radiation exposure for pregnant women and infants/young children just in case. Radiation treatment for other cancers also involves an elevated risk of NHL and other second cancers; however, in these cases, NHL usually develops later in life as adult NHL.

Epstein-Barr Virus (EBV): While the linkages are not well understood, individuals with Epstein-Barr Virus have a higher risk of developing NHL. This is especially true in Africa where EBV has been linked to almost 90% of Burkitt lymphoma diagnoses. It has been linked with about 15% of Burkitt lymphoma here in the United States and is also linked to post-organ transplant lymphomas.

Can Non-Hodgkin Lymphoma Be Prevented?

There is a simple answer to this critical question: no. Most children diagnosed with non-Hodgkin lymphoma have no risk factors or lifestyle issues that could have been altered or changed in any way to prevent the development of this disease. While it is entirely natural and very common to search for a cause or something to blame when a child is diagnosed with NHL (or any type of cancer), it is important that parents and guardians understand that there is nothing that they could have done differently to prevent this disease.

There are two notable exceptions. First, a small percentage of diagnoses are associated with a compromised immune system such as HIV infection. HIV-positive mothers are encouraged to take active steps during and after pregnancy to reduce the risk of passing HIV along to their children. Second, NHL may develop as a second cancer stemming from a prior cancer treatment or immune-suppressing drugs taken to facilitate an organ transplant. Obviously, in these cases, the small risk of developing NHL in the future must be weighed against the need to treat a potentially life-threatening disease in the present.

More about Childhood Non-Hodgkin Lymphoma Cancers:

• About Childhood Non-Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Non-Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Non-Hodgkin Lymphoma Cancer?
• Non-Hodgkin Lymphoma Cancer Treatment
• Non-Hodgkin Lymphoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Non-Hodgkin Lymphoma Cancer?
• After Treatment – Living as a Childhood Non-Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

About Childhood Non-Hodgkin Lymphoma (NHL)

Non-Hodgkin Lymphoma (NHL) is a specific type of cancer that begins in the body’s immune system, in cells known as lymphocytes. While there are a variety of different classifications of NHL—usually based on key features such as the size, shape, and growth pattern of the cancerous cells—most children are diagnosed with one of three distinct types of NHL (the other types are mainly diagnosed in adults). While all three types of childhood NHL are considered “high grade” (growing aggressively) and diffuse, they are all treated somewhat differently.

The three types of Non-Hodgkin Lymphoma in children are:

• Lymphoblastic lymphoma (LBL): LBL begins in very young lymphocytes known as lymphoblasts, similar to acute lymphoblastic leukemia (ALL). In most cases, LBL develops from T cells (precursor T-lymphoblastic lymphomas) in the thymus, but occasionally in the tonsils or lymph nodes. B-cell NHL (precursor B-lymphoblastic lymphomas) can develop in lymph nodes in the chest or neck. LBL is an aggressive, quickly growing cancer that can cause breathing problems.
• Burkitt lymphoma (small, non-cleaved cell lymphoma): Burkitt lymphoma accounts for about 40% of all childhood NHL diagnoses in the United States (primarily in boys between the ages of 5-10). In most cases, Burkitt lymphoma starts in the abdomen. In certain parts of Africa, Burkitt lymphoma accounts for nearly all NHL diagnoses and more than 50% of all childhood cancers, and usually forms in the jaw or face. Burkitt lymphoma is one of the fastest-growing cancers and must be treated quickly and aggressively.
• Large cell lymphomas: Large cell lymphomas grow from more mature T or B cells. While this type of lymphoma can develop almost anywhere, it grows more slowly than other lymphomas and is unlikely to spread into the bone marrow or the brain. It is more common in older children and teens. There are two main subtypes: anaplastic large cell lymphoma (ALCL) and diffuse large B-cell lymphoma (DLBCL).

Detection and Diagnosis of Non-Hodgkin Lymphoma

In most cases, diagnosis of non-Hodgkin lymphoma in children comes when a parent or guardian notices unusual symptoms of illness or concern. Although in most cases, these types of symptoms are caused by any number of common childhood illnesses or infections, if your child’s pediatrician believes that lymphoma or another type of cancer may be present, he or she will recommend that you visit an oncologist or other specialist for further diagnostic testing. In most cases, NHL will be diagnosed and classified with a biopsy, in which some or all of the cancerous cells are surgically removed and examined under a microscope.

Childhood NHL can cause a variety of signs and symptoms of illness, usually stemming from where in the body the cancer is growing. Some of the most common symptoms of NHL include:

• Enlarged lymph nodes (lumps under the skin that can be seen or felt) usually in the neck, underarm, collar bone, or groin. They are generally not painful (unlike enlarged lymph nodes resulting from infection).
• Swollen abdomen caused by a tumor in or near the belly or a build-up of fluid because of a tumor. Other signs that of a lymphoma in the abdomen include feeling full after consuming only a small amount of food, pain, nausea, and/or vomiting.
• Shortness of breath or cough caused by a lymphoma growing in the thymus or lymph nodes in the chest.
• Swelling in the face, neck, arms, and upper chest may be caused by a lymphoma pressing on artery and veins near the heart, such as the superior vena cava. Other symptoms of so-called SVC syndrome include trouble breathing, headaches, dizziness, and loss of consciousness.

In addition, NHL can cause so-called B symptoms, which are generalized symptoms but often indicate the presence of an aggressive and quickly-growing lymphoma. B symptoms include:

• Fever and/or chills
• Unexplained weight loss
• Night sweats
• Fatigue (feeling very tired)

Finally, NHL may create symptoms stemming from too few health blood cells (because the lymphoma has spread to the bone marrow and is forcing out healthy blood cells). These symptoms include severe and/or frequent infections, easy bruising and/or bleeding, and fatigue, pale skin, and anemia.

More about Childhood Non-Hodgkin Lymphoma Cancers:

• About Childhood Non-Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Non-Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Non-Hodgkin Lymphoma Cancer?
• Non-Hodgkin Lymphoma Cancer Treatment
• Non-Hodgkin Lymphoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Non-Hodgkin Lymphoma Cancer?
• After Treatment – Living as a Childhood Non-Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

After Treatment: Living as a Childhood Hodgkin Lymphoma Survivor

The good news is that for most patients, the long-term prognosis for childhood Hodgkin lymphoma is excellent. For patients who have been through months or even years of difficult chemotherapy and radiation therapy, it is easy to see the final treatment—the declaration of “cancer free” or even “cured”—as the final destination of a long journey. Survivorship, however, is in fact its own journey, and one that can also be extremely challenging, both physically and emotionally.

For many survivors of childhood Hodgkin lymphoma, the emotional impact of survivorship—especially in the short term—can be two-fold. First, reintegrating back into a “normal” life is not always as easy as it sounds. For adolescents and young adults who have been forced away from school and social activities, managing the pressures of returning to academics and reestablishing friendships can be exceedingly and surprisingly stressful. Second, both survivors and their families must cope with the fear that the cancer will return (recurrence). This anxiety is extremely common among cancer survivors, and can be especially difficult to cope with during routine follow-up scans and exams.

Survivorship also comes with a lengthy list of potential long-term physical side effects, also known as “late effects”, which may result from the chemotherapy and radiation required to treat Hodgkin lymphoma. While treatment mechanisms are improving significantly, with more targeted treatments and smaller and more effective dosages, the risk of serious and long-term side effects has not yet been eliminated. It is critical that survivors follow a long-term follow-up program, potentially for the rest of the child’s adult life.

Some of the more common late effects include:

• Second cancers: Hodgkin lymphoma survivors are a higher risk for developing a second type of cancer later in the life, usually relating to the chemotherapy or radiation needed to treatment the original cancer. Chemotherapy has been linked to the development of blood cancers such as leukemia, while radiation therapy has been linked to cancers in the organs adjacent to the treated area. For instance, young women who undergo chest radiation are more likely to develop breast cancer; chest radiation has also been linked to a higher risk of lung cancer. While second cancers cannot be prevented, it is important to maintain a healthy lifestyle, avoid known cancer-triggers such as tobacco use, and follow an aggressive early-screening schedule as appropriate.
• Fertility problems: Cancer treatments in adolescents and young adults can cause long-term problems relating to fertility. For men, chemotherapy can temporarily or even permanently impact sperm production, while for women the late effects can be even more complex, affecting both the menstrual cycle and/or the reproductive organs. Luckily, steps can be taken in advance of treatment—such as banking sperm or surgically moving ovaries—to reduce the long-term impact on reproductive capabilities.
• Increased risk of infection: Although the mechanisms are not yet well-understood, Hodgkin lymphoma survivors may have a compromised immune system, leaving them more vulnerable to bacterial and/or viral infections. This is especially problematic for individuals who have had their spleen removed (significantly less common now than in the past). Thus, it is especially important for survivors to get regular flu shots and other standard vaccines, and in some cases even get vaccines for certain bacteria.
• Organ problems: Depending on the intensity of chemotherapy and the intensity and location of radiation, survivors can develop health problems in adjacent organs that may have been adversely impacted by treatment. The most common concerns are usually thyroid problems (hypothyroidism), heart disease, stroke, and lung damage.

Obviously, the goal of any treatment program is to maximize the chances of recovery while minimizing the risk for short- and long-term side effects. Despite rapid improvements in available cancer treatments, we have not yet found a way to fully eliminate these risks. Yet there are several steps survivors and their families can take to monitor for and identify late effects as early as possible, thereby increasing the likelihood that they can be successfully treated.

• Develop a survivorship plan that includes a regular schedule of follow-up visits and early screening tests, a list of potential late effects, and a wellness plan.
• Stick to all scheduled tests, exams, and screenings, even if they cause anxiety about recurrence.
• Alert your physician to any health problems or concerns immediately, even if they seem insignificant. Unfortunately, many late effects cannot be diagnosed until symptoms become apparent.
• Maintain accurate and up-to-date health records. As you see new physicians throughout your life, it is important that they have access to your medical history and all cancer treatments.
• Maintain health insurance. Especially for young adults, the temptation to save money and go without can be overwhelming. Yet late effects can crop up suddenly and treatment can be expensive without insurance.

More about Childhood Hodgkin Lymphoma Cancers:

• About Childhood Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Hodgkin Lymphoma Cancer?
• Childhood Hodgkin Lymphoma Cancer Treatment
• Childhood Hodgkin Lymphoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Hodgkin Lymphoma Cancer?
• After Treatment – Living as a Childhood Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

What is Childhood Hodgkin Lymphoma?

Hodgkin lymphoma is a specific type of cancer that starts within white blood cells called lymphocytes found in the lymph (or lymphatic) system. Hodgkin lymphoma (HL) can be diagnosed in individuals of all ages, but is most prevalent in adolescents between the ages of 15-19 and again in adults older than 55. It is rare in children under the age of five. When classified as a type of childhood cancer, HL accounts for about 6% of all childhood cancers; however, most statistics relating to HL do not distinguish between diagnoses in children, adolescents, and adults.

There are two different types of Hodgkin lymphoma: classical Hodgkin lymphoma accounts for 9 out of 10 cases, with a more rare form known as Nodular lymphocyte-predominant Hodgkin lymphoma accounting for about 1 out of 10 cases. Classical Hodgkin lymphoma is characterized by the presence of a specific cancer cell known as Reed-Sternberg cells. As it name implies, Nodular lymphocyte-predominant Hodgkin lymphoma is characterized instead by lymphocyte-predominant cells. Both forms are distinct from non-Hodgkin lymphoma.

Expected Life Span: Outcomes and Prognosis of Childhood Hodgkin Lymphoma

As with most types of cancers, prognosis statistics for Hodgkin lymphoma are generally given in terms of “five-year survival rates”, which provides an average of the number of individuals who are alive five years after diagnosis. As always, however, these statistics are general: your child’s specific outlook will depend specifically on the unique nature of your child’s diagnosis, the stage of the disease at the time of diagnosis, and the assessment of risk at diagnosis. Generally speaking, however, the outlook for HL is favorable; it is usually fairly responsive to both chemotherapy and radiation therapy and was the first type of cancer to be “cured” with radiation therapy alone or in combination with chemotherapy.

When discussing five-year survival statistics for HL, the National Cancer Institute utilizes a staging system known as SEER with three distinct groupings. The most recent data in the SEER database is from 2008 to 2014; however, in 2014 most oncologists and researchers began utilizing a different staging system known as the Lugano classification. Therefore, we have provided five-year survival statistics here using the SEER system, but will discuss staging below as categorized by the more recent Lugano classification, as that is more likely what oncologists will use for a current diagnosis.

• Localized: limited to one lymph node cluster or lymphoid organ, or has spread to only one organ beyond the lymph system. The 5-year survival rate for localized HL is 92%.
• Regional: has spread from one lymph node area to an organ close by, is located in two or more lymph node clusters but only on one side of the body, or is “bulky”. The 5-year survival rate for regional HL is 93%.
• Distant: has spread to a more distant part of the body such as the lungs or bone marrow, or to lymph node clusters above and below the diaphragm. The 5-year survival rate for distant HL is 78%.

Hodgkin Lymphoma Stages: Lugano Classification

Today, oncologists have moved away from the less descriptive groupings used in the SEER database towards a more descriptive system known as the Lugano classification system. In either case, however, the stage of the disease at diagnosis helps determine the extent to which the cancer has spread, the intensity of required treatment, and the long-term outlook.

The Lugano classification involves a three-tied staging system:

The first step involves a letter classification: A, B, E, or S. HL with a “B” classification is more advanced and usually requires more intensive treatment:

• A: no symptoms at diagnosis
• B: “B” symptoms at diagnosis: fever, 10% or more weight loss, and/or night sweats
• E: the cancer has spread to an organ or tissue that is next to but not part of the lymph system
• S: cancer has spread to the spleen

The second step involves four distinct phases: I, II, III, and IV:

• Stage I: The cancer is found in one or more lymph nodes, but only one lymph node cluster.
• Stage II: The cancer is found in two or more lymph node clusters, either above or below the diaphragm.
• Stage III: The cancer is found in one or more lymph node cluster both above and below the diaphragm.
• Stage IV: The cancer is found in one or more organs and in lymph nodes adjacent to those organs, or is in only one organ but has spread to lymph nodes distant from that organ, or is in the liver, lung, or bone marrow.

The third step involves assigning a risk group, usually stemming from whether the tumor can be considered “bulky”, defined as five centimeters or larger, as well as the presence of “B” symptoms:

• Low risk: Stage I or Stage II with no bulky tumors or “B” symptoms
• Intermediate risk: Stage I or II with either bulky tumors or “B” symptoms; or Stage III and IV without any “B” symptoms
• High risk: Stage III or IV accompanied by “B” symptoms

More about Childhood Hodgkin Lymphoma Cancers:

• About Childhood Hodgkin Lymphoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Hodgkin Lymphoma Cancer
• What are the signs and symptoms of Childhood Hodgkin Lymphoma Cancer?
• Childhood Hodgkin Lymphoma Cancer Treatment
• Childhood Hodgkin Lymphoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Hodgkin Lymphoma Cancer?
• After Treatment – Living as a Childhood Hodgkin Lymphoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

Childhood Neuroblastoma: Staging

When a child is diagnosed with most types of childhood cancer, including neuroblastoma, a critical part of the diagnosis is the “stage” of the disease. The stage of the disease indicates how far the disease has spread or progressed from the site of the original tumor. In the case of neuroblastoma, there are currently two methodologies in use to determine staging.

The International Neuroblastoma Risk Group Staging System (INRGSS) relies upon the results of imaging tests such CT, MRI, or MIBG scans. Using this method, the stage can be determined in advance of a specific treatment protocol. This system utilizes a four-stage classification:

• L1: the tumor remains confined to one area of the body and has not spread
• L2: the tumor has only slightly spread but has at least one image-defined risk factor (IDRF)
• M: the tumor has spread to a distant area of the body
• MS: the tumor has spread only to the skin, liver, and/or bone marrow in a child who is younger than 18 months. To fall into this category, scans must demonstrate that no more than 10% of marrow cells are cancerous and the cancer has not spread to the bones.

Increasingly, many oncologists are moving towards this methodology because it enables them to develop a stage and risk assessment before deciding upon an appropriate treatment, especially for children for whom surgery is not appropriate or not immediately appropriate.

The International Neuroblastoma Staging System (INSS) assesses the stage of the disease after surgery to remove all or most of the tumor. This is the more traditional staging system, and is still the system utilized by the COG to determine risk groupings (see below). The stages in this system are:

• Stage 1: the tumor has not spread and can be entirely removed by surgery.
• Stage 2A: the tumor has not spread but cannot be removed entirely by surgery.
• Stage 2B: the tumor has not spread but cannot be entirely removed by surgery. Nearby lymph nodes contain some neuroblastoma cells.
• Stage 3: the tumor has begun to spread and (1) the cancer cannot be removed by surgery and has crossed to the other side of the body; (2) the cancer has not crossed the midline to the other side of the body except in the lymph nodes; and/or (3) the tumor is in the middle of the body and is growing out on both sides, either directly or through the lymph nodes, and cannot be removed entirely by surgery.
• Stage 4: the tumor has spread to distant parts of the body such as lymph nodes, bone, bone marrow, skin, liver, and/or other organs.
• Stage 4S: only applicable in children under 1 year of age. The cancer has potentially spread to lymph nodes, liver, skin, and/or bone marrow but only on one side of the body. Scans must show that no more than 10% of marrow cells are tumorous and the cancer has not spread to the bones.

Neuroblastoma Prognosis Factors

In addition to the stage of the disease, oncologists also determine so-called “prognosis factors”, which can help indicate how a specific neuroblastoma may respond to treatment. These prognosis factors may also impact risk assessment and long-term prognosis. For neuroblastoma, oncologists will look at:

• Age
• Tumor histology
• DNA ploidy
• MYCN gene amplifications
• Chromosome changes
• Neurotrophin (nerve growth factor) receptors

Childhood Neuroblastoma: Prognosis Statistics

For childhood neuroblastoma, statistics relating to prognosis and five-year survival rates are currently maintained by the Children’s Oncology Group (COG) and therefore utilize COG risk-groupings: low risk, intermediate risk, and high risk. These risk group classifications are determined by the disease’s stage and prognosis factors as described above.

As always when discussing five-year survival rates, it is important to note that these statistics provide only a statistical average for each classification; your child’s prognosis will depend on his or her specific diagnosis, health, response to treatment, etc.

Low Risk: “Low risk” neuroblastoma patients have a five-year survival rate that is greater than 95%. The low risk group includes neuroblastomas within the following categories:

• Any Stage 1 diagnosis
• Stage 2A or 2B; under 1 year of age
• Stage 2A or 2B; older than 1 year of age; with no extra copies of the MYCN gene
• Stage 2A or 2B; older than 1 year; with extra copies of the MYCN gene; with a favorable histology
• Stage 4S with favorable histology, hyperdiploid, and 0 extra copies of the MYCN gene

Intermediate Risk: “Intermediate risk” neuroblastoma have a five-year survival rate of about 90-95%. The intermediate risk group incorporates diagnoses within these specific categories:

• Stage 3; under 1 year of age; 0 extra copies of the MYCN gene
• Stage 3; older than 1 year; 0 extra copies of the MYCN gene; with a favorable histology
• Stage 4; less than 1 year of age; no copies of the MYCN gene
• Stage 4S; 0 extra copies of the MYCN gene; with normal DNA ploidy and/or an unfavorable histology

High Risk: “High risk” neuroblastoma have a five-year survival rate of about 40-50%. A high risk diagnosis involves the following classifications:

• Stage 2A or 2B, older than 1 year of age; extra copies of the MYCN gene; with an unfavorable histology
• Stage 3 (regardless of age) with extra copies of the MYCN gene
• Stage 3; over 18 months old; an unfavorable histology
• Stage 4 with extra copies of the MYCN gene
• Stage 4 and over 18 months old
• Stage 4; between 12 and 18 months old; with extra copies of the MYCN gene, unfavorable histology, and/or a DNA index of 1
• Stage 4S with extra copies of the MYCN gene

More about Childhood Neuroblastoma Cancers:

• About Childhood Neuroblastoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Neuroblastoma Cancer
• What are the signs and symptoms of Childhood Neuroblastoma Cancer?
• Childhood Neuroblastoma Cancer Treatment
• Childhood Neuroblastoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Neuroblastoma Cancer?
• After Treatment – Living as a Childhood Neuroblastoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate

Childhood Neuroblastoma: Treatment Options

Neuroblastoma is a form of childhood cancer that begins in the early development of nerve cells. Because this rare form of cancer usually begins when the sympathetic nervous system is developing in an embryo or fetus, it occurs most often in infants and very young children, and is extremely rare in children over the age of 10. And because it begins when nerve cells are developing very quickly, the cancer’s development within each child can vary widely: some neuroblastomas grow and spread very quickly while other neuroblastomas grow very slowly. In some cases, the cancerous cells simply disappear on their own, while in other cases, the cancerous cells mature into normal nerve cells. Therefore, treatment for neuroblastoma often depends, upon other factors, on the stage and risk grouping of the cancer, as well as on the age of the child.

Treatment for Low Risk Neuroblastoma

Any time a child is diagnosed with cancer—neuroblastoma or otherwise—the goal is to utilize the least intensive treatment to minimize short- and long-term side effects while maximizing the damage to the cancerous cells. For children with low risk neuroblastoma, treatment may be as simple as frequent and routine monitoring to determine whether the tumor may die or mature into normal cells without intervention.

Surgery may be the only required treatment if all or most of the tumorous cells can be reached and safely removed. Even if it is not possible to remove the entire tumor with surgery, in some cases any remaining cancerous cells may die or mature on their own without the need for any additional intervention.

Chemotherapy may be required if the tumor cannot be safely or effectively removed with surgery or if the tumor continues to grow abnormally after surgery. If the tumor is causing symptoms due to its proximity to a nearby organ, a short course of chemotherapy may be utilized in advance of surgery to reduce the size of the tumor. A similar treatment method may be utilized to make the tumor more accessible to a surgeon.

Generally speaking, oncologists try to avoid the use of radiation therapy in young children due to the extremely high risk of negative short- and long-term side effects.

Treatment for Intermediate Risk Neuroblastoma

For children with intermediate risk neuroblastoma, treatment almost always involves a combination of surgery and chemotherapy. A typical course of treatment usually involves four to eight cycles of chemotherapy before and following surgery. One or more rounds of radiation therapy may be utilized only if the cancerous cells do not respond to chemotherapy or if the tumor is causing symptoms that require emergency treatment; again, the goal is to avoid the use of radiation therapy whenever possible in young children.

Treatment for High Risk Neuroblastoma

Children with high risk neuroblastoma will require aggressive treatment that usually involves an intensive mix of chemotherapy, surgery, radiation therapy, stem cell transplant(s), retinoid therapy, and immunotherapy.

Treatment usually starts with extremely aggressive chemotherapy designed to destroy as much of the cancer as possible, sometimes coupled with surgery to remove any remaining tumors. This phase of treatment is known as induction. If induction is successful, it will send the cancer into remission.

Induction is usually followed by a consolidation phase, which involves additional intensive chemotherapy treatments to rid the body of any remaining cancerous cells. Because this phase of treatment often destroys normal bone marrow as well as the cancer, it usually involves one or more stem cell transplants to help the body replace the damaged bone marrow. Stem cell transplants may be followed by immunotherapy to help boost the body’s ability to find and destroy cancer cells on its own, as well as radiation therapy at the primary tumor site to prevent recurrence.

If induction is successful, treatment will move to a maintenance phase involving a combination of additional immunotherapy and retinoid therapy. Retinoids are a type of differentiating agent that is believed to help some types of cancer cells mature into normal cells. The goal of this phase of treatment is to reduce the risk of recurrent neuroblastoma.

More about Childhood Neuroblastoma Cancers:

• About Childhood Neuroblastoma Cancer – Detection and Diagnosis
• Causes, Risk Factors, and Prevention of Childhood Neuroblastoma Cancer
• What are the signs and symptoms of Childhood Neuroblastoma Cancer?
• Childhood Neuroblastoma Cancer Treatment
• Childhood Neuroblastoma Cancer – Stages and Prognosis
• What is the expected life span of Childhood Neuroblastoma Cancer?
• After Treatment – Living as a Childhood Neuroblastoma Cancer Survivor

Learn More About the Different Types of Childhood Cancers:

• Childhood Brain Tumor Cancer (Brain Stem Tumors)
• Spinal Cord Tumor Cancer
• Childhood Neuroblastoma Cancers
• Childhood Hodgkin Lymphoma Cancers
• Non-Hodgkin Lymphoma Cancers
• Wilms tumor (Kidney Tumors)
• Rhabdomyosarcoma
• Retinoblastoma
• Bone cancer (including osteosarcoma and Ewing sarcoma)
• Leukemia Cancers: Acute lymphocytic (lymphoblastic) leukemia (ALL) Acute myelogenous leukemia (AML); Juvenile myelomonocytic leukemia (JMML)
• Hepatoblastoma (Liver Cancer)
• Rhabdoid Tumors

Together, we can make a difference.
Donate today because kids can’t fight cancer alone®.

About American Childhood Cancer Organization

The American Childhood Cancer Organization was founded in 1970 by parents of children and adolescents diagnosed with cancer. As the nation’s oldest and largest grassroots organization dedicated to childhood cancer, ACCO is committed to shaping policy, supporting research, raising awareness, and providing free educational resources to kids with cancer, survivors, and their families. Additionally, ACCO is the sole U.S. member of Childhood Cancer International (CCI) and has helped support more than half a million families over the past 50 years. Help make childhood cancer a national health priority because kids can’t fight cancer alone®. 

For more information about how ACCO can help your family, call 855.858.2226 or visit:

• Who We Are
• How to Get Involved
• How to Donate