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What is the expected lifespan of a child with leukemia?

Childhood leukemia is often pointed to as childhood cancer research’s success story. Just 60 years ago, almost no child with leukemia survived more than a few years, but today, thanks to new discoveries and advances in treatment, 90% of children with the most common type of leukemia will survive. That progress is certainly worth celebrating, but these statistics don’t tell the whole story. Let’s take a closer look at what these numbers really mean for children with leukemia.

What We Mean by “Survival”

When we talk about long-term survival for any childhood cancer, including leukemia, it is important to understand that oncologists and cancer researchers look at the five-year survival rate, or how many children remain cancer-free five years after the end of treatment. In general, children who are still cancer-free after five years are considered “cured” of the disease. 

Thanks to advances in treatment methods, the five-year survival rate for childhood leukemia has greatly improved over the past several decades. The five-year survival rate for acute lymphoblastic leukemia (ALL) is now 90%. The five-year survival rate for acute myelogenous leukemia (AML) is lower, at 60-70%. Moreover, the rates can vary greatly depending on subtype and other factors.

These numbers do not, however, provide a specific prognosis for any given child. They are only averages compiled from treated cases of childhood leukemia across the country. Your child’s prognosis and long-term outlook after treatment will be heavily dependent on your child’s diagnosis, response to treatment, and general health.

Prognosis Factors for Childhood Leukemia

Prognosis factors are a series of measurements that your child’s oncology team may use to estimate the degree of risk posed by the cancer and to determine the most promising treatment plan. There are several key prognosis factors that oncologists use when dealing with a leukemia diagnosis. In general, these prognosis factors are the same for ALL and AML, but they do not seem to play as great a role in either guiding treatment or predicting outcomes for AML.

  • Risk group: A cancer can be classified as standard risk, high risk, or very high risk. These groupings help determine the intensity of treatment and may impact long-term prognosis.
  • Age at diagnosis: For B- cell ALL, children between the ages of 1 and 9 seem to have a more positive prognosis than children under the age of 1 or over the age of 10. Age does not appear to be a prognosis factor in T-cell ALL and AML.
  • Initial white blood cell count: Very high white blood cell counts at diagnosis is generally considered high risk or very high risk.
  • Subtype: There are many subtypes of leukemia, and some tend to be less aggressive and more responsive to treatment than others. For example, children diagnosed with pre-B, common, or early pre-B-cell ALL seem to have a more positive prognosis than children with mature B-cell leukemia, although B-cell ALL can also have a more positive prognosis if treated with intensive chemotherapy.
  • Gender: In general, girls seem to have a slightly better prognosis than boys, though this gap has shrunk in recent years thanks to today’s advanced treatment options.
  • Race/ethnicity: African-American and Hispanic children may have a slightly worse prognosis than other ethnicities. 
  • Spread to other organs: If the leukemia has spread into the fluid around the brain and spinal cord, and the testicles in boys, it is usually classified as high-risk or very high-risk.
  • Number of chromosomes and chromosome translocations: Some studies have begun to link longer-term prognosis with the number of chromosomes within the leukemia cells, as well as with translocations between specific chromosomes (when part of a chromosome breaks off and attaches to another).
  • Response to treatment: The initial reduction of leukemia cells in the bone marrow during the first one to two weeks of chemotherapy may help determine long-term prognosis. If the leukemia does not respond as expected in this time frame, most oncologists will move to a more intensive treatment protocol.

Life for Childhood Leukemia Survivors

For several years after finishing treatment for leukemia, children will need to have regular exams to check for signs that the cancer has returned, as well as to monitor for side effects of treatment. Some side effects may appear during treatment or soon after the end, while others might not surface until adulthood.

Side effects of childhood leukemia treatment can include:

  • Social and emotional challenges
  • Developmental delays/learning problems
  • Growth delays
  • Secondary cancers
  • Heart, lung, and bone problems
  • Fertility problems

While all childhood leukemia survivors have a greater risk of developing certain health problems as a result of their treatment, most side effects can be managed with proper medical care. It’s important that, even as adults, survivors continue to have regular health checks and are upfront with their healthcare providers about their cancer history.

Kaydence’s Story: Surviving ALL

Kaydence is no ordinary 7-year-old. She’s a talented budding artist with a penchant for donkeys, and she’s a survivor of acute lymphoblastic leukemia.

There was nothing ordinary about Kaydence’s cancer journey, either. She was found to have two rare chromosome mutations that classified her cancer as very high risk, and when she didn’t respond to the initial treatment, her parents and treatment team decided to move forward with CAR T-cell immunotherapy, a novel treatment that trains the patient’s own immune cells to target and kill the cancer cells.

It wasn’t an easy road. She spent 10 days on life support fighting septic shock two weeks after diagnosis. She went into anaphylactic shock after her T-cell infusion. She had to re-learn how to stand, walk, use her hands and fingers, and go to the toilet. But despite all the setbacks, Kaydence’s treatment was successful. She has been in remission since March 2019. Her immune system is still suppressed, so she has to take extra precautions to make sure she doesn’t get sick, and her doctors continue to monitor her closely for side effects or any signs of her cancer returning. But for her part, Kaydence is enjoying being her 7-year-old self: painting and crafting, playing with her siblings, and just being a normal kid.

September is Leukemia and Lymphoma Awareness Month. Help kids like Kaydence by making a donation to the American Childhood Cancer Organization to honor their fight during Leukemia Awareness Month. Your gift helps provide educational resources and support programs for children with cancer, survivors, and their families, as well as raise awareness about childhood cancer and the need for more research.

Together, we can make a difference.

Donate today… because kids can’t fight cancer alone®.

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